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ASCO™ 273 and 373 Pneumatic Pinch Valves
ASCO Series 273-373
The ASCO Series 273 is a 2-way normally-closed or normally-open pressure-operated pinch valve designed to assure integrity of high-purity liquids in biotechnology, pharmaceuticals, diagnostics, single-use technology (SUT), and food and beverage markets.
Typical applications include single-use bioreactors, Tangential Flow Filtration (TFF), and Chromatography skids.

The ASCO Series 373 is a 3-way normally-closed or normally-open pneumatic pinch valve also designed for single-use systems, including chromatography applications. Pneumatic pinch valves control the flow of the media by using pressurized air to operate the pinching mechanism and open or close the valve. The hermetic separation of valve control mechanism and the process media within the flexible, single-use tubing prevents contamination. A large range of body sizes are available to accommodate a wide variety of tubing sizes.

ASCO Series 273/373 Pneumatic Pinch Valves

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ASCO™ 273 and 373 Pneumatic Pinch Valves


Valve Type
2-Way Normally Open (NO) and Normally Closed (NC)
Material of construction
2-Way: Anodized Aluminum and Stainless Steel
Tube Range (OD)
2-Way: 1/4", 3/8", 1/2", 3/4", 1"
Tube Material
Silicone, cflex374, 082 and Tygon
Tube Hardness
55 - 80 Shore A (Gamma Radiated)
Tube Media Pressure
Up to 90 PSI (up to 6 BAR), depending on size and tubing material
Air operating / Piloting pressure
70 PSI – 145 PSI (4.8 BAR – 10 BAR)
Ambient Temperature
32°F to 104°F (0°C to + 40°C)
T-Groove for switch contact
Feedback on valve position status (Ex. ASCO Series 494)
Inert Gases or Liquids


  • Innovative design
    • No contact with the process media
    • Easy insertion and removal of flexible tubing
  • Industry Leading Performance and Reliability
    • High tube pinching cycles
    • Better retention and protection of tubing during pinching cycles
  • Operator Safety
    • Easy to use built-in protective safety guard
    • Manual override allows for tube insertion removal without valve actuation
  • Unmatched Product Support
    • Local sales support and product specialists help find solutions to customer specific applications
    • Technical service and online support